Vaccinations are still an importent preventive measure. In this context, the vaccination of immunocompromised people is of significant importance. On the one hand, children should be vaccinated along the recommendations of the German standing committee on vaccination (STIKO) at the Robert Koch Institute. On the other hand, this concerns also older people (aged 60+), whom we strongly recommend getting vaccinated against the most important pathogens of bacterial pneumonia – the so-called pneumococci. The vaccination of these two age groups represents an effective protection against diseases transmitted from grandchildren to grandparents. Pneumonia is the most common cause for sepsis.
Also people who have had their spleen removed benefit from vaccination. The spleen's main function is to act as a filter for your blood and to remove old red blood cells. Furthermore the spleen plays an important role in the immune system. Especially encapsulated bacteria, like the pathogens causing pneumonia or meningitis, are detected in the bloodstream by the spleen which activates a targeted immune response. People without a spleen don't have such an alarm system. An infection can thus develop into a life-threatening sepsis.
SPLEEN OFF is the acronym of a study which was conducted in patients with a missing spleen or a splenic dysfunction.
It is known that these patients have an increased risk to develop a pneumoccocal sepsis. Therefore, patients who have had their spleen removed should absolutely get vaccinated.
You'll find further information about the study at: http://asplenie-net.org/spleen-off/